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生命科学与技术学院Tiffany Horng研究组(巨噬细胞免疫代谢学)招聘博士后1名
日期:2018-10-22    浏览量:895

Tiffany Horng研究组即将从Harvard. T.H. Chan School of Public Health(哈佛公卫学院)搬到上海科技大学生命科学与技术学院建立课题组。本课题組致力于研究极具动力性及调节多种生理的巨噬细胞。我們利用細胞生物学,分子生物学,小鼠模型,以及最先进的代谢組学等手段來阐述巨噬细胞代谢的机制,参与的信号传导网路,以及相互之间的调控作用。我們的目標是为巨噬细胞调节的多种生理和病理狀态如先天免疫、炎症等提供前瞻思路及可能的诊疗手段。欲了解本课题组研究内容,请参考Covarrubias et al, eLIFE 2016 (PMID 26894960); Byles et al, Nature Communications 2013 (PMID 24280772); Langston et al, Frontiers in Immunology 2017 (PMID 28197151)以及https://www.hsph.harvard.edu/tiffany-horng/

 

本课题组重视科研人员的职业发展,提供各种科学培训机会以及与企业合作交流的机会,支持组员参加学术会议活动,特别优秀者可被推荐去美国高校深造。

 

一、 岗位职责

1. 能独立开展课题研究,并协助PI指导和培养学生及其他工作人员。

2. 积极参与或主导经费申请及协助PI进行课题组的日常管理。

3. 准备学术报告和撰写学术论文。在国际一流期刊上发表高水平论文。


二、 招聘条件

1. 拥有或即将获得分子细胞生物学,免疫学,代谢学或相关领域的博士学位。

2. 在国际期刊上发表过论文的申请者优先;35岁以下。

3. 良好的中,英文表达和书写能力。

4. 熟悉细胞生物学,免疫学,分子生物学, 代谢学常规实验技术者优先。

5. 热爱科研,拥有强烈的进取心和敬业精神。

6. 优良的人际交往和沟通能力。

7. 较强的学术训练基础,独力思考,工作能力。

8. 身心健康,能长期稳定工作。

 

三、待遇

按照上海科技大学相关规定执行,根据个人具体情况,提供具有竞争力的薪酬和福利。上海科技大学提供良好的工作环境和生活待遇。

 

四、申请方式

1. 请感兴趣并符合这些条件的申请人通过人才招聘系统(http://jobs.shanghaitech.edu.cn/)提交应聘申请,请填写完整应聘材料。应聘流程为:注册、填写并提交基本信息、应聘选择岗位。

2.请上传个人中、英文简历(包括学习工作经历,主要研究工作内容,代表论文论著清单)。

3.请上传三位推荐人的联系方式。

4.应聘时间:2018年7月起至招满为止。联系人:Dr. Tiffany Horng (thorng@hsph.harvard.edu). 邮件标题请注明“Tiffany Horng研究组博士后申请”。

注:未通过初篩者恕不另行通知。



Job Description

The Macrophage Metabolism Laboratory of Dr. Tiffany Horng is moving from Harvard. T.H. Chan School of Public Health to open a new laboratory at the School of Life Science and Technology (SLST) at the ShanghaiTech University in Shanghai, China. We are looking for an ambitious and highly driven postdoctoral scientist to work with Dr. Horng to elucidate mechanisms by which cellular metabolism supports macrophage biology in a variety of physiological and pathophysiological contexts.

 

The lab’s research is in the burgeoning field of immunometabolism. Drawing on our extensive expertise in studying macrophage biology and metabolism, we seek to understand the molecular and cellular mechanisms by which metabolism is coordinated with signal transduction, transcription, and gene regulation in controlling macrophage activation by immune signals and signals of infection. Towards this end, the lab employs a combination of tissue culture models, molecular biology, metabolomics, genetics, biochemistry, and mouse models.

 

In our studies, we have discovered that the AKT-mTOR pathway, a central metabolic pathway, integrates metabolic signals to control of macrophage activation, especially energetically demanding aspects of macrophage activation. The Akt-mTOR pathway controls production of Ac-CoA, the metabolic substrate for histone acetylation, to regulate histone acetylation and expression of inducible genes during macrophage activation. In contrast, aberrant activity of the Akt-mTOR pathway leads to inappropriate gene induction and macrophage activation. In ongoing studies, we have been studying how mitochondrial metabolism impinges on chromatin to regulate gene induction and macrophage activation. For more information about the lab’s research, please see: https://www.hsph.harvard.edu/tiffany-horng/. For representative publications, please see: Covarrubias et al, eLIFE 2016 (PMID 26894960); Byles et al, Nature Communications 2013 (PMID 24280772), and Langston et al, Frontiers in Immunology 2017 (PMID 28197151).

 

In Dr. Horng’s lab, the postdoctoral fellow will address fundamental questions by which cellular metabolism supports macrophage activation, such as:

How does mitochondrial metabolism and other aspects of cellular metabolism influence macrophage activation in different contexts?

How does macrophage metabolism influence its interactions with parenchymal cells?

How does dysregulated metabolism contribute to aberrant macrophage activation in pathophysiological contexts?

Specific projects for the postdoctoral fellow will be determined through discussions with Dr. Horng, depending on his/her skills and experience as well as the availability and timeliness of the projects.

 

The successful candidate will have a strong track record and will demonstrate excellent inter-personal, organizational and time management skills and good English communication skills. He/she must have a strong passion for science and the ability to work independently as well as part of a team. Applications from adventurous foreign individuals are also highly encouraged.

 

The research will be based in the modern open lab space in the SLST in ShanghaiTech University, situated in the heart of Zhangjiang Hi-Tech Park in the Pudong Science District in Shanghai. The initial term of this post is 24 months, but the term can be extended up to 4 years, with the possibility of the promotion to Research Assistant Professor. The annual salary will be decided based on the University salary scale, and the experience and qualification of the candidate. All postdocs in ShanghaiTech will have access to various social benefits provided by the university, including an in-campus accommodation and contribution to social security.

 

A detailed job description and instructions for the application process are described below. Any informal enquiries regarding the position should be directed to Dr. Horng via e-mail: thorng@hsph.harvard.edu.

 

Key Responsibilities

To design the course of research projects under the guidance of Dr. Horng.

To design experiments and conduct them accurately and reproducibly.

To analyse and interpret data objectively and critically.

To report and discuss results with Dr. Horng and other lab members.

70%

To present the work at internal and external seminars and at national and international scientific conferences.

To contribute to the preparation of publications and applications for funding.

20%

To assist Dr. Horng with supervision of students and/or junior research staff working in support of the projects.

To cooperate with Drs Horng and lab members in organising lab regents and equipment and maintaining high standards for the lab space.

10%


Person’s profile

Education & qualifications

A PhD or an equivalent degree in a biomedical science.

Scientific knowledge and skills (essential)

Basic knowledge in molecular cell biology.

Logical thinking and critical thinking.

Publication in good (e.g., SCI) journals.

Experience and basic skills in molecular cell biology, biochemistry, mammalian tissue culture, and working with mice, as reflected in the publication record.

Specialised knowledge & skills (desirable)

Knowledge of immunology and/or metabolism is highly preferred.

Experience and basic skills in working with macrophages, immunological techniques, and/or metabolic assays are desirable.

Interpersonal & communication skills (essential)

Ability to present and discuss the work and research topics clearly in written and spoken English with the supervisor and academic co-workers.

Ability to cooperate with and support colleagues and to maintain cohesive and collaborative relationships.

Relevant experience & skills (desirable)

Experience in presenting at international conferences

Experience in supervising students or junior colleagues

Experience in communicating and collaborating with scientists in relevant or different disciplines

 

Application process

Qualified applicants should provide the following items in English:

1. Cover Letter describing suitability for the position in broad terms as well as professional goals

2. Curriculum Vitae including academic background and work experience

3. List of publications and up to 3 representative publications as PDFs

4. Contact details of two to three referees, one of which should include most recent supervisor/line manager. References will be requested after the initial selection.

 

Qualified applicants interested in this position should submit the above documents directly to Dr. Horng via email: thorng@hsph.harvard.edu. Simultaneously, applicants should complete the online application form using the Shanghai University of Science and Technology Talent Recruitment System (http://jobs.shanghaitech.edu.cn/) following the instructions. Shortlisted candidates will be contacted and interviewed by Dr. Horng.

 

The selection process will commence after July 15st 2018 and will continue until the position is filled.







 
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