Tiffany Horng研究组即将从Harvard. T.H. Chan School of Public Health（哈佛公卫学院）搬到上海科技大学生命科学与技术学院建立课题组。本课题組致力于研究极具动力性及调节多种生理的巨噬细胞。我們利用細胞生物学，分子生物学，小鼠模型，以及最先进的代谢組学等手段來阐述巨噬细胞代谢的机制，参与的信号传导网路，以及相互之间的调控作用。我們的目標是为巨噬细胞调节的多种生理和病理狀态如先天免疫、炎症等提供前瞻思路及可能的诊疗手段。欲了解本课题组研究内容，请参考Covarrubias et
al, eLIFE 2016 (PMID 26894960); Byles
et al, Nature Communications 2013
(PMID 24280772); Langston et al, Frontiers
in Immunology 2017 (PMID 28197151)以及https://www.hsph.harvard.edu/tiffany-horng/。
4. 熟悉细胞生物学，免疫学，分子生物学， 代谢学常规实验技术者优先。
4.应聘时间：2018年7月起至招满为止。联系人：Dr. Tiffany Horng (email@example.com). 邮件标题请注明“Tiffany Horng研究组博士后申请”。
The Macrophage Metabolism Laboratory of Dr. Tiffany Horng is moving
from Harvard. T.H. Chan School of Public Health to open a new laboratory at the
School of Life Science and Technology (SLST) at the ShanghaiTech University in
Shanghai, China. We are looking for an ambitious and highly driven postdoctoral
scientist to work with Dr. Horng to elucidate mechanisms by which cellular
metabolism supports macrophage biology in a variety of physiological and
The lab’s research is in the burgeoning field of immunometabolism.
Drawing on our extensive expertise in studying macrophage biology and
metabolism, we seek to understand the molecular and cellular mechanisms by
which metabolism is coordinated with signal transduction, transcription, and
gene regulation in controlling macrophage activation by immune signals and
signals of infection. Towards this end, the lab employs a combination of tissue
culture models, molecular biology, metabolomics, genetics, biochemistry, and
In our studies, we have discovered that the AKT-mTOR pathway, a
central metabolic pathway, integrates metabolic signals to control of
macrophage activation, especially energetically demanding aspects of macrophage
activation. The Akt-mTOR pathway controls production of Ac-CoA, the metabolic
substrate for histone acetylation, to regulate histone acetylation and
expression of inducible genes during macrophage activation. In contrast,
aberrant activity of the Akt-mTOR pathway leads to inappropriate gene induction
and macrophage activation. In ongoing studies, we have been studying how
mitochondrial metabolism impinges on chromatin to regulate gene induction and
macrophage activation. For more information about the lab’s research, please
see: https://www.hsph.harvard.edu/tiffany-horng/. For representative
publications, please see: Covarrubias et al, eLIFE 2016 (PMID 26894960); Byles et al, Nature Communications 2013 (PMID 24280772), and Langston et al, Frontiers in Immunology 2017 (PMID
In Dr. Horng’s lab, the postdoctoral fellow will address fundamental
questions by which cellular metabolism supports macrophage activation, such as:
How does mitochondrial
metabolism and other aspects of cellular metabolism influence macrophage
activation in different contexts?
How does macrophage metabolism
influence its interactions with parenchymal cells?
How does dysregulated
metabolism contribute to aberrant macrophage activation in pathophysiological
Specific projects for the postdoctoral fellow will be determined
through discussions with Dr. Horng, depending on his/her skills and experience
as well as the availability and timeliness of the projects.
candidate will have a strong track record and will demonstrate excellent inter-personal, organizational and time management
skills and good English communication skills. He/she must have a strong passion for science and the
ability to work independently as well as part of a team. Applications
from adventurous foreign individuals are also highly encouraged.
The research will be based in the
modern open lab space in the SLST in ShanghaiTech University, situated in the
heart of Zhangjiang Hi-Tech Park in the Pudong Science District in Shanghai.
The initial term of this post is 24 months, but the term can be extended up to
4 years, with the possibility of the promotion to Research Assistant Professor.
The annual salary will be decided based on the University salary scale, and the
experience and qualification of the candidate. All postdocs in ShanghaiTech
will have access to various social benefits provided by the university,
including an in-campus accommodation and contribution to social security.
A detailed job description and
instructions for the application process are described below. Any informal
enquiries regarding the position should be directed to Dr. Horng via e-mail: firstname.lastname@example.org.
design the course of research projects under the guidance of Dr. Horng.
design experiments and conduct them accurately and reproducibly.
analyse and interpret data objectively and critically.
report and discuss results with Dr. Horng and other lab members.
present the work at internal and external seminars and at national and
international scientific conferences.
contribute to the preparation of publications and applications for funding.
assist Dr. Horng with supervision of students and/or junior research staff
working in support of the projects.
cooperate with Drs Horng and lab members in organising lab regents and
equipment and maintaining high standards for the lab space.
or an equivalent degree in a biomedical science.
knowledge and skills (essential)
knowledge in molecular cell biology.
thinking and critical thinking.
in good (e.g., SCI) journals.
and basic skills in molecular cell biology, biochemistry, mammalian tissue
culture, and working with mice, as reflected in the publication record.
knowledge & skills (desirable)
of immunology and/or metabolism is highly preferred.
and basic skills in working with macrophages, immunological techniques,
and/or metabolic assays are desirable.
& communication skills (essential)
to present and discuss the work and research topics clearly in written and
spoken English with the supervisor and academic co-workers.
to cooperate with and support colleagues and to maintain cohesive and collaborative
experience & skills (desirable)
in presenting at international conferences
in supervising students or junior colleagues
in communicating and collaborating with scientists in relevant or different
Qualified applicants should provide the following items in English:
1. Cover Letter describing
suitability for the position in broad terms as well as professional goals
2. Curriculum Vitae including
academic background and work experience
3. List of publications and up to
3 representative publications as PDFs
4. Contact details of two to three
referees, one of which should include most recent supervisor/line manager.
References will be requested after the initial selection.
applicants interested in this position should submit the above documents
directly to Dr. Horng via email: email@example.com.
Simultaneously, applicants should complete the online application form using
the Shanghai University of Science and Technology Talent Recruitment System
(http://jobs.shanghaitech.edu.cn/) following the instructions. Shortlisted
candidates will be contacted and interviewed by Dr. Horng.
process will commence after July 15st 2018 and will continue until
the position is filled.