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生命科学与技术学院Tiffany Horng研究组(巨噬细胞免疫代谢学)招聘助理研究员1名
日期:2018-8-1    浏览量:558

Tiffany Horng研究组即将从Harvard. T.H. Chan School of Public Health(哈佛公卫学院)搬到上海科技大学生命科学与技术学院为建立课题组。本课题組致力于研究极具动力性及调节多种生理的巨噬细胞。我們利用細胞生物学,分子生物学,小鼠摸型,以及最先进的代谢組学等手段來阐述巨噬细胞代谢的机制,参与的信号传导网路,以及相互之间的调控作用。我們的目標是为巨噬细胞调节的多种生理和病理狀态如先天免疫、炎症等提供前瞻思路及可能的诊疗手段。欲了解本课题组研究内容,请参考Covarrubias et al, eLIFE 2016 (PMID 26894960); Byles et al, Nature Communications 2013 (PMID 24280772); Langston et al, Frontiers in Immunology 2017 (PMID 28197151)以及https://www.hsph.harvard.edu/tiffany-horng/

 

本课题组重视科研人员的职业发展,提供各种科学培训的机会以及与企业合作交流的机会,支持组员参加学术会议活动,特别优秀者可被推荐去美国高校深造。欢迎对本领域研究有兴趣和热情的优秀青年加盟本团体。


一、 岗位职责:

1. 协助PI设计、参与和指导实验室各类基金,人才项目,以及对外合作的申请和执行。

2. 参与或主导实验室日常科研和管理工作,协助PI指导和培养研究组员。

3. 在PI指导下独力开展课题研究,在国际一流期刊上发表高水平论文。


二、 招聘条件:

1. 拥有分子细胞生物学,免疫学,代谢学或相关的博士学位,优先考虑具有博士后研究工作经历的申请人。

2. 在国际期刊上发表过高水平论文以及在国内外高水平研究型大学,科研院所学习和工作过的申请者优先。

3. 良好的中,英文表达和书写能力。

4. 责任心强,以及拥有优良的人际交往,沟通能力,和团队协作精神。

5. 热爱科研,拥有强烈的进取心和敬业精神。

6. 身心健康,能长期稳定工作。

 

三、待遇:

按照上海科技大学相关规定执行,根据个人具体情况,提供具有竞争力的薪酬和福利。上海科技大学提供良好的工作环境和生活待遇。

 

四、申请方式

1. 请感兴趣并符合这些条件的申请人通过人才招聘系统(http://jobs.shanghaitech.edu.cn/)提交应聘申请,请填写完整应聘材料。应聘流程为:注册、填写并提交基本信息、应聘选择岗位。

2. 请上传个人中、英文简历(包括学习工作经历,主要研究工作内容,代表论文论著清单)。

3. 请上传三位推荐人的联系方式。

4. 应聘时间:2018年7月起至招满为止。联系人: Tiffany Horng (thorng@hsph.harvard.edu). 邮件标题请注明“Tiffany Horng研究组助理研究员申请”。

注:未通过初篩者恕不另行通知。




Job Description

The Macrophage Metabolism Laboratory of Dr. Tiffany Horng is moving from Harvard. T.H. Chan School of Public Health to open a new laboratory at the School of Life Science and Technology (SLST) at the ShanghaiTech University in Shanghai, China. We are looking for an ambitious and highly driven Research Assistant Professor to work with Dr. Horng to elucidate mechanisms by which cellular metabolism supports macrophage biology in a variety of physiological and pathophysiological contexts. The research will be based in the modern open lab space in the SLST in ShanghaiTech University, situated in the heart of Zhangjiang Hi-Tech Park in the Pudong Science District in Shanghai. Very competitive salary and benefits will be provided for this position.

 

The lab’s research is in the burgeoning field of immunometabolism. Drawing on our extensive expertise in studying macrophage biology and metabolism, we seek to understand the molecular and cellular mechanisms by which metabolism is coordinated with signal transduction, transcription, and gene regulation in controlling macrophage activation by immune signals and signals of infection. Towards this end, the lab employs a combination of tissue culture models, molecular biology, metabolomics, genetics, biochemistry, and mouse models.

 

In our studies, we have discovered that the AKT-mTOR pathway, a central metabolic pathway, integrates metabolic signals to control of macrophage activation, especially energetically demanding aspects of macrophage activation. The Akt-mTOR pathway controls production of Ac-CoA, the metabolic substrate for histone acetylation, to regulate histone acetylation and expression of inducible genes during macrophage activation. In contrast, aberrant activity of the Akt-mTOR pathway leads to inappropriate gene induction and macrophage activation. In ongoing studies, we have been studying how mitochondrial metabolism impinges on chromatin to regulate gene induction and macrophage activation. For more information about the lab’s research, please see: https://www.hsph.harvard.edu/tiffany-horng/. For representative publications, please see: Covarrubias et al, eLIFE 2016 (PMID 26894960); Byles et al, Nature Communications 2013 (PMID 24280772), and Langston et al, Frontiers in Immunology 2017 (PMID 28197151). Specific projects for the Research Assistant Professor will be determined through discussions with Dr. Horng, depending on his/her skills and experience as well as the availability and timeliness of the projects.

 

The successful candidate will have a strong track record and will demonstrate excellent inter-personal, organizational and time management skills and excellent English communication skills. He/she must have a strong passion for science and the ability to work independently as well as part of a team. Applications from adventurous foreign individuals are also highly encouraged.

 

A detailed job description and instructions for the application process are described below. Any informal enquiries regarding the position should be directed to Dr. Horng via e-mail: thorng@hsph.harvard.edu.

 

Key Responsibilities

The successful candidate will carry out his/her own research projects, under the guidance of Dr. Horng, with the goal of publication in international peer-reviewed journals. In addition, he/she is expected to present the work at internal and national and international seminars and conferences, and to contribute to the preparation of applications for funding. He/she will also assist Dr. Horng with the supervision of students and/or junior research staff working in support of the projects, as well as with the general organization and maintenance of the lab. Dr. Horng guarantees a working environment that will help the Research Assistant Professor to expand his or her knowledge in experimental research, interact with professional colleagues from around the world, and advance his/her career.

 

Requirements

Education & qualifications 

A PhD or an equivalent degree in a biomedical science from an accredited institution.
At least 2 years of postdoctoral fellowship experience.

Scientific knowledge and skills (essential)

Basic knowledge in molecular cell biology.

Logical thinking and critical thinking.

Publication in international peer-reviewed academic journals.

Experience and basic skills in molecular cell biology, biochemistry, mammalian tissue culture, and working with mice, as reflected in the publication record.

Specialised knowledge & skills (desirable)

Knowledge of immunology and/or metabolism is highly preferred.

Experience and basic skills in working with macrophages, immunological techniques, and/or metabolic assays are desirable.

Interpersonal & communication skills (essential)

Ability and willingness to present and discuss the work and research topics clearly in written and spoken English and Chinese with the supervisor and academic co-workers.

Ability to cooperate with and support colleagues and to maintain cohesive and collaborative relationships.

Relevant experience & skills (desirable)

Experience in presenting at international conferences

Experience in supervising students or junior colleagues

Experience in communicating and collaborating with scientists in relevant or different disciplines

 

Application process

Qualified applicants should provide the following items in English:

1. Cover Letter describing research experience and career plans

2. Curriculum Vitae including academic background and work experience

3. List of publications and up to 3 representative publications as PDFs

4. Contact details of three referees, one of which should include most recent supervisor. References will be requested after the initial selection.

 

Qualified applicants interested in this position should submit the above documents directly to Dr. Horng via email: thorng@hsph.harvard.edu. Simultaneously, applicants should complete the online application form using the Shanghai University of Science and Technology Talent Recruitment System (http://jobs.shanghaitech.edu.cn/) following the instructions. Shortlisted candidates will be contacted and interviewed by Dr. Horng.

 

The selection process will commence after July 15st 2018 and will continue until the position is filled. 


 

 

 
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