Tiffany Horng研究组即将从Harvard. T.H. Chan School of Public Health（哈佛公卫学院）搬到上海科技大学生命科学与技术学院为建立课题组。本课题組致力于研究极具动力性及调节多种生理的巨噬细胞。我們利用細胞生物学，分子生物学，小鼠摸型，以及最先进的代谢組学等手段來阐述巨噬细胞代谢的机制，参与的信号传导网路，以及相互之间的调控作用。我們的目標是为巨噬细胞调节的多种生理和病理狀态如先天免疫、炎症等提供前瞻思路及可能的诊疗手段。欲了解本课题组研究内容，请参考Covarrubias et al, eLIFE 2016 (PMID 26894960); Byles et al, Nature
Communications 2013 (PMID 24280772); Langston et al, Frontiers in Immunology 2017 (PMID 28197151)以及https://www.hsph.harvard.edu/tiffany-horng/。
4. 应聘时间：2018年7月起至招满为止。联系人: Tiffany Horng (firstname.lastname@example.org). 邮件标题请注明“Tiffany Horng研究组助理研究员申请”。
Metabolism Laboratory of Dr. Tiffany Horng is moving from Harvard. T.H. Chan
School of Public Health to open a new laboratory at the School of Life Science
and Technology (SLST) at the ShanghaiTech University in Shanghai, China. We are
looking for an ambitious and highly driven Research Assistant Professor to work
with Dr. Horng to elucidate mechanisms by which cellular metabolism supports
macrophage biology in a variety of physiological and pathophysiological
contexts. The research will be based in the modern open lab space in the SLST
in ShanghaiTech University, situated in the heart of Zhangjiang Hi-Tech Park in
the Pudong Science District in Shanghai. Very competitive salary and benefits
will be provided for this position.
lab’s research is in the burgeoning field of immunometabolism. Drawing on our
extensive expertise in studying macrophage biology and metabolism, we seek to
understand the molecular and cellular mechanisms by which metabolism is
coordinated with signal transduction, transcription, and gene regulation in controlling
macrophage activation by immune signals and signals of infection. Towards this
end, the lab employs a combination of tissue culture models, molecular biology,
metabolomics, genetics, biochemistry, and mouse models.
our studies, we have discovered that the AKT-mTOR pathway, a central metabolic
pathway, integrates metabolic signals to control of macrophage activation,
especially energetically demanding aspects of macrophage activation. The
Akt-mTOR pathway controls production of Ac-CoA, the metabolic substrate for
histone acetylation, to regulate histone acetylation and expression of
inducible genes during macrophage activation. In contrast, aberrant activity of
the Akt-mTOR pathway leads to inappropriate gene induction and macrophage
activation. In ongoing studies, we have been studying how mitochondrial
metabolism impinges on chromatin to regulate gene induction and macrophage
activation. For more information about the lab’s research, please see:
https://www.hsph.harvard.edu/tiffany-horng/. For representative publications,
please see: Covarrubias et al, eLIFE 2016 (PMID 26894960); Byles et al, Nature
Communications 2013 (PMID 24280772), and Langston et al, Frontiers in Immunology 2017 (PMID
28197151). Specific projects for the Research Assistant Professor will be
determined through discussions with Dr. Horng, depending on his/her skills and
experience as well as the availability and timeliness of the projects.
candidate will have a strong track record and will demonstrate excellent inter-personal, organizational and time management
skills and excellent English communication skills. He/she must have a strong passion for science and the
ability to work independently as well as part of a team. Applications
from adventurous foreign individuals are also highly encouraged.
A detailed job description and instructions for the
application process are described below. Any informal enquiries regarding the
position should be directed to Dr. Horng via e-mail: email@example.com.
The successful candidate will carry out his/her own research projects,
under the guidance of Dr. Horng, with the goal of publication in international
peer-reviewed journals. In addition, he/she is expected to present the work at
internal and national and international seminars and conferences, and to
contribute to the preparation of applications for funding. He/she will also
assist Dr. Horng with the supervision of students and/or junior research staff
working in support of the projects, as well as with the general organization
and maintenance of the lab. Dr. Horng guarantees a working environment that
will help the Research Assistant Professor to expand his or her knowledge in
experimental research, interact with professional colleagues from around the
world, and advance his/her career.
A PhD or an equivalent degree in a biomedical science from an accredited institution.
At least 2 years of postdoctoral fellowship experience.
knowledge and skills (essential)
knowledge in molecular cell biology.
thinking and critical thinking.
in international peer-reviewed academic journals.
and basic skills in molecular cell biology, biochemistry, mammalian tissue
culture, and working with mice, as reflected in the publication record.
knowledge & skills (desirable)
of immunology and/or metabolism is highly preferred.
and basic skills in working with macrophages, immunological techniques,
and/or metabolic assays are desirable.
& communication skills (essential)
and willingness to present and discuss the work and research topics clearly
in written and spoken English and Chinese with the supervisor and academic
to cooperate with and support colleagues and to maintain cohesive and
experience & skills (desirable)
in presenting at international conferences
in supervising students or junior colleagues
in communicating and collaborating with scientists in relevant or different
applicants should provide the following items in English:
1. Cover Letter describing research experience and
2. Curriculum Vitae including academic background
and work experience
3. List of publications and up to 3 representative
publications as PDFs
4. Contact details of three referees, one of which
should include most recent supervisor. References will be requested after the
applicants interested in this position should submit the above documents
directly to Dr. Horng via email: firstname.lastname@example.org.
Simultaneously, applicants should complete the online application form using
the Shanghai University of Science and Technology Talent Recruitment System (http://jobs.shanghaitech.edu.cn/) following the instructions. Shortlisted
candidates will be contacted and interviewed by Dr. Horng.
selection process will commence after July 15st 2018 and will
continue until the position is filled.