The Cell Cycle in Development
Laboratory is moving from the University of Cambridge to open a new laboratory
at the School of Life Science and Technology (SLST) at the ShanghaiTech
University in Shanghai,
China. We are looking for an ambitious,
highly-driven postdoctoral scientist to work with Dr Kimata to elucidate the functions of the cell cycle-regulating
proteins in coupling cell cycle exit to cell fate determination and cellular
differentiation during the metazoan development.
The Kimata lab aims to understand the molecular
and cellular mechanisms by which the cell cycle is coordinated with
developmental and homeostatic processes in the metazoan organism. We combine the model systems of Drosophila
melanogaster and mammalian organoids with in vitro cell culture, biochemistry, proteomics and bioinformatics,
and have been working with international collaborators including David Glover,
Marc de la Roche (University of Cambridge), Renata Basto (Curie Institute), and
Hiroyuki Yamano (UCL).
The focus of our research has been on the evolutionarily
conserved multisubunit ubiquitin ligase, the anaphase promoting complex/cyclosome
(APC/C). We have recently discovered:
regulates the transcriptional activity of one of the major extracellular
signalling pathways, the Wnt signalling pathway, during the retinal development
in Drosophila (Martins et al., 2017 Developmental Cell);
APC/C ensures cell fate determination of the neural stem
cell and the oocyte through the regulation of the centrosome (Meghini
et al., 2016, Nature Communications, Braun et al., bioRxiv).
For further information of our
research, please visit the Kimata lab websites: https://www.gen.cam.ac.uk/research-groups/kimata (University of Cambridge), or http://www.kimatalab.com/ (the lab’s own website).
researcher will address fundamental biological questions centring around the
cell cycle control in the multicellular organism such as:
· How are cell cycle exit and cellular
differentiation coupled, and what are the role of cell cycle-regulating
proteins in this coupling?
· How are these coupling mechanisms or the
uncoupling of these processes involved in human disease?
· How is cell proliferation regulated in
vivo, and how can it be controlled at will?
projects for the researcher will be determined through discussions with Dr
Kimata, depending on their skills and experience as well as the availability and
the timeliness of the projects.
candidate will have a strong track record and will demonstrate excellent inter-personal, organisational and time management skills
and good English communication skills. An individual with a strong passion for science and collaborative and can-do attitudes will best fit to our lab. Applications from adventurous foreign
individuals are also highly encouraged.
The research will be based in the modern
open lab space in the SLST in ShanghaiTech University, situated in the heart of Zhangjiang
Hi-Tech Park in the Pudong
Science District in Shanghai. The
initial term of this post is 24 months, but the term can be extended up to 4
years, with the possibility of the promotion to Research Assistant Professor. The
annual salary will be decided based on the University salary scale, and the
experience and qualification of the candidate.
The detailed job description and the instruction of the
application process are described below. Any informal enquiries regarding the
role and the research project should be directed to Dr Kimata via e-mail: firstname.lastname@example.org.
To design the course of research projects under the
guidance of Dr Kimata.
To design experiments and conduct them accurately and
To analyse and interpret data objectively and
To report and discuss results with Dr Kimata and other lab
To present the work at internal and external seminars
and at national and international scientific conferences.
To contribute to the preparation of publications and
applications for funding.
To assist Dr Kimata with supervision of students and/or
junior research staff working in support of the projects.
To cooperate with Dr Kimata and lab members in organising
lab regents and equipment and in maintaining high standard of the lab space.
A PhD or
an equivalent degree in a biomedical science.
knowledge and skills (essential)
knowledge in molecular cell biology, genetics, developmental biology,
bioinformatics and statistics.
thinking and critical thinking.
and skills in molecular cell biology or biochemical experiments.
and skills in microscopy and quantitative image analysis.
knowledge & skills (desirable)
on Drosophila biology and methodology.
on developmental biology and/or the cell cycle research.
and skills in experiments using Drosophila.
in confocal and light microscopy.
in any of the following areas: cell culture, mammalian organoid culture,
biochemistry, advanced microscopic techniques super-resolution microscopy, EM),
& communication skills (essential)
to present and discuss the work and research topics clearly in written and
spoken English with the supervisor and academic co-workers.
to cooperate with and support colleagues and to maintain cohesive and
experience & skills (desirable)
in the scientific literature
in presenting at international conferences
in supervising students or junior colleagues
in communicating and collaborating with scientists in relevant or different
Qualified applicants are requested to provide the following
items (in English):
1. A cover letter describing your interests and professional
2. Curriculum Vitae including academic background and work
3. List of publications and PDF files of three best papers (if
4. Contact details of two or three referees, one
of which must be your most recent supervisor/line manager. References will be requested after the initial selection.
Applicants who are interested in this position should submit the above
documents directly to Dr Yuu Kimata via e-mail: email@example.com. The
formal selection process will commence after 30th June 2018 and will continue until the position is filled.