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Positions for Platform of Antibody Screening, SIAIS, ShanghaiTech Unviersity

时间:2019-09-04浏览:11设置

The platform of antibody screening in Shanghai Institute for Immunochemical Studies(SIAIS) is led by Prof. Sachdev Sidhu. We are recruiting technicians and scientists according to following profiles.


Job1: Technician 

Job Description 

This job will focus on the expression and characterization of proteins using standard biochemical and biophysical techniques for the aim of identifying, developing and optimizing antibodies for therapeutic application. This job requires self-initiation, attention to detail, strong note-keeping skills, frequent, transparent and timely reporting of activities and a responsiveness to feedback.  The ideal candidate can take direction, but work both independently and together as part of a team in a dynamic environment to contribute to the collective aims of the lab. They will be open and flexible to learning new techniques and developing new skills while maintaining a core array of regularly used biochemical, biophysical and instrumental techniques. 

Responsibilities

•Work within a team on various antibody characterization & optimization projects in parallel 

•Maintain complete, accurate, and timely record of experiments and data analysis

•Report on day to day progress in a transparent and timely manner

•Maintain attention to detail, critical thinking, and an aptitude for learning 

•Exhibit a pro-active attitude, and strong interpersonal, collaborative and oral communication skills 

•Work collaboratively in an interdisciplinary scientific team 

•Demonstrate strong time management skills and ability to manage multiple projects in parallel 

•Use molecular techniques to sub-clone molecules of interest in to different expression vectors and verify by determination and analysis of DNA sequences

•Express and characterize antibodies and antibody-related molecules in vitro using biochemical, biophysical and cell-based assays

•Present data at group and inter-departmental meetings clearly and succinctly and with scientific rigour

Educational and experience requirements

•An MSc in Immunology, Oncology, Molecular Biology, or a related field with 2-4 years industry experience in the relevant fields (antibody/protein engineering and/or immuno-oncology)

•Strong written and oral communication skills in English 

•Preferred experience in antibody/protein engineering, structural biology, or immuno-oncology 

•Demonstrated ability to work productively in a fast-paced and collaborative team environment

•Track record of demonstrating analytical skills, bench skills and problem-solving skills 

•Past experience in automation or high throughput screening is preferred

•Preference given to those with demonstrated experience in the following techniques including PCR, molecular cloning, protein expression and purification, protein and DNA electrophoresis, basic sequence analysis, ELISA assays, size exclusion exchange chromatography, and basic cell culture.



Job2:Scientist

Job Description 

This job will entail the expression and characterization of proteins using standard biochemical and biophysical techniques for the aim of identifying, developing and optimizing antibodies for therapeutic application. This job requires self-initiation, attention to detail, strong note-keeping skills, frequent, transparent and timely reporting of activities and a responsiveness to feedback.  The ideal candidate can take direction, but work independently and together as part of a team with other scientists from both within and outside of the lab in a dynamic environment to support and contribute to the collective aims of the lab. They will be open and flexible to learning and developing new techniques and skills while maintaining and core array of regularly used biochemical, biophysical and instrumental techniques.

Responsibilities

•Work within a team on various antibody characterization & optimization projects in parallel 

•Maintain complete, accurate, and timely record of experiments and data analysis

•Report on day to day progress in a transparent and timely manner

•Communicate frequently with lab management by teleconference

•Exhibit a pro-active attitude, and strong interpersonal, collaborative and oral communication skills 

•Ability to work productively in a fast-paced and collaborative team environment

•Maintain attention to detail, critical thinking, and an aptitude for learning 

•Use molecular techniques to sub-clone molecules of interest in to different expression vectors and verify by sequence determination 

•Express and characterize antibodies and antibody-related molecules in vitro using biochemical, biophysical and cell-based assays

•Develop cell-based functional assays using engineered cell lines and primary cells

•Troubleshoot experiments with minimal guidance. Independently analyze data and provide accurate summary to management

•Constantly monitor the workflow, identify any gaps and execute on the solutions to enhance the efficiency of the process

•Present data at group meetings clearly, succinctly and with scientific rigor

•Keep abreast of the latest technology and advancement in antibody engineering and therapeutic areas

•Develop in-depth scientific knowledge in area of research focus, propose new ideas and contribute to decisions on project direction intellectually

•Provide quality-controlled materials to and manage collaborations with external groups

Educational and experience requirements

•A PhD in Immunology, Oncology, Molecular Biology, or a related field with 3-5 years industry experience in the relevant fields (antibody/protein engineering and/or immuno-oncology)

•Strong written and oral communication skills in English 

•Preferred experience in antibody/protein engineering, structural biology and immuno-oncology 

•Demonstrated experience in the biochemical and biophysical analysis of proteins 

•Demonstrated experience in cell-based assay development and multi-color FACS analysis

•Broad knowledge in disease biology is preferred

•Past experience in automation or high throughput screening is preferred


Application Procedure:

Submit a letter outlining your research interest, a CV to shane.miersch@utoronto.ca, cc to hr_siais@shanghaitech.edu.cn


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